AT101 acetic acid

Catalog No. A13578

AT101 acetic acid对映体AT101与Bcl-2，Bcl-xL和Mcl-1结合，Ki分别为0.32μM，0.48μM和0.18μM；不抑制BIR3域和BID。

Technical details

Catalog Num	A13578
M. Wt	578.61
Formula	C30H30O8.C2H4O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	866541-93-7
Synonyms	AT-101, AT 101
SMILES	CC1=C(C(=C2C(=C1)C(=C(C(=C2C=O)O)O)C(C)C)O)C3=C(C=C4C(=C3O)C(=C(C(=C4C(C)C)O)O)C=O)C.CC(=O)O

Biological Activity

AT101 acetic acid对映体AT101与Bcl-2，Bcl-xL和Mcl-1结合，Ki分别为0.32μM，0.48μM和0.18μM；不抑制BIR3域和BID。

Targets

Mcl-1 (Cell-free assay)	Bcl-2 (Cell-free assay)	Bcl-xL (Cell-free assay)
0.18 μM(Ki)	0.32 μM(Ki)	0.48 μM(Ki)

Solubility *

In vitro (25°C)	DMSO	108 mg/mL (186.65 mM)
	Water	Insoluble
	Ethanol	83 mg/mL
In vivo	2% DMSO+30% PEG 300+2% Tween 80+ddH2O	3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.28 mL	86.41 mL	172.83 mL
0.5 mM	3.46 mL	17.28 mL	34.57 mL
1 mM	1.73 mL	8.64 mL	17.28 mL
5 mM	0.35 mL	1.73 mL	3.46 mL

*The above data is based on the productmolecular weight 578.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.