CA-074 Methyl Ester

Catalog No. A13593

CA-074 Methyl Ester是CA-074的细胞渗透性类似物，用作不可逆组织蛋白酶B抑制剂。据报道，CA-074甲酯在啮齿动物模型中抑制骨吸收，并显示在体外抑制B16黑素瘤细胞侵袭。

Product Citations

Qian Chu, .et al. Patulin induces pyroptosis through the autophagic-inflammasomal pathway in liver, Food Chem Toxicol, 2021, Jan;147:111867 PMID: 33217525
Ye Tao, .et al. Autophagic-CTSB-inflammasome axis modulates hepatic stellate cells activation in arsenic-induced liver fibrosis, Chemosphere, 2020, Mar;242:124959 PMID: 31669990
Ming Sun, .et al. Patulin Induces Autophagy-Dependent Apoptosis through Lysosomal-Mitochondrial Axis and Impaired Mitophagy in HepG2 Cells, J Agric Food Chem, 2018, Nov 21;66(46):12376-12384 PMID: 30392375
Xueyan Wu, .et al. Mono(2-ethylhexyl) phthalate induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis in human endothelial cells, Food Chem Toxicol, 2017, Aug;106(Pt A):273-282 PMID: 28579546

Technical details

Catalog Num	A13593
M. Wt	397.5
Formula	C19H31N3O6
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	147859-80-1
Synonyms	CA-074 Me
SMILES	CCCNC(=O)C1C(O1)C(=O)NC(C(C)CC)C(=O)N2CCCC2C(=O)OC

Biological Activity

Targets

Solubility *

In vitro	DMSO	77 mg/mL (193.72 mM)
	Water	77 mg/mL (193.72 mM)
	Ethanol	6 mg/mL (15.09 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.16 mL	125.79 mL	251.57 mL
0.5 mM	5.03 mL	25.16 mL	50.31 mL
1 mM	2.52 mL	12.58 mL	25.16 mL
5 mM	0.5 mL	2.52 mL	5.03 mL

*The above data is based on the productmolecular weight 397.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.