VR23

Catalog No. A13650

VR23是一个小分子，可有效抑制胰蛋白酶样蛋白酶体（IC50 = 1 nM），胰凝乳蛋白酶样蛋白酶体（IC50 = 50-100 nM）和半胱天冬酶样蛋白酶体（IC50 = 3uM）的活性。

Technical details

Catalog Num	A13650
M. Wt	477.88
Formula	C19H16ClN5O6S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1624602-30-7
Synonyms	VR-23, VR 23
SMILES	ClC1=CC2=C(C(N3CCN(S(C4=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C4)(=O)=O)CC3)=CC=N2)C=C1

Biological Activity

Targets

Trypsin-like proteasomes	Chymotrypsin-like proteasomes	Caspase-like proteasomes
1 nM	50-100 nM	3 μM

Solubility *

In vitro	DMSO	Warmed: 29 mg/mL (60.68 mM)
	Water	Warmed: 5 mg/mL (10.46 mM)
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.93 mL	104.63 mL	209.26 mL
0.5 mM	4.19 mL	20.93 mL	41.85 mL
1 mM	2.09 mL	10.46 mL	20.93 mL
5 mM	0.42 mL	2.09 mL	4.19 mL

*The above data is based on the productmolecular weight 477.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.