EGFR Inhibitor

Catalog No. A13673

EGFR inhibitor是一种可透过细胞的4,6-二取代嘧啶化合物，可选择性抑制EGFR激酶，在体外的IC50值为21 nM，可阻断细胞中的受体自身磷酸化。

Technical details

Catalog Num	A13673
M. Wt	413.4
Formula	C21H18F3N5O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	879127-07-8
Synonyms	Epidermal Growth Factor Receptor Inhibitor
SMILES	C1CC1C(=O)NC2=CC=CC(=C2)NC3=NC=NC(=C3)NC4=CC=CC(=C4)C(F)(F)F

Biological Activity

EGFR inhibitor是一种可透过细胞的4,6-二取代嘧啶化合物，可选择性抑制EGFR激酶，在体外的IC50值为21 nM，可阻断细胞中的受体自身磷酸化。

Solubility *

In vitro	DMSO	79 mg/mL (191.09 mM)
	Water	<1 mg/mL
	Ethanol	2 mg/mL (4.83 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.19 mL	120.95 mL	241.9 mL
0.5 mM	4.84 mL	24.19 mL	48.38 mL
1 mM	2.42 mL	12.09 mL	24.19 mL
5 mM	0.48 mL	2.42 mL	4.84 mL

*The above data is based on the productmolecular weight 413.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience

EGFR Inhibitor

Technical details

Biological Activity

Solubility *

Preparing Stock Solutions