BMS-863233 (XL-413)

Catalog No. A13677

BMS-863233，也称为XL-413，是一种具有潜在抗肿瘤活性的细胞分裂周期7同系物（CDC7）激酶抑制剂。

Product Citations

Gijs Zonderland, .et al. The TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transition, Mol Cell, 2022, Sep 15;82(18):3350-3365 PMID: 36049481
Wang C, .et al. Inducing and exploiting vulnerabilities for the treatment of liver cancer, Nature, 2019, Oct 2 PMID: 31578521

Technical details

Catalog Num	A13677
M. Wt	326.18
Formula	C14H13Cl2N3O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1169562-71-3
Synonyms	BMS-863233; BMS863233; BMS 863233; XL-413; XL413; XL 413
SMILES	C1C[C@H](NC1)C2=NC(=O)C3=C(N2)C4=C(O3)C=CC(=C4)Cl.Cl

Biological Activity

BMS-863233，也称为XL-413，是一种具有潜在抗肿瘤活性的细胞分裂周期7同系物（CDC7）激酶抑制剂。

Targets

Cdc7	Pim1	CK2
3.4 nM	42 nM	212 nM

Solubility *

In vitro	DMSO	Insoluble
	Water	Warmed: 43 mg/mL (131.82 mM)
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	30.66 mL	153.29 mL	306.58 mL
0.5 mM	6.13 mL	30.66 mL	61.32 mL
1 mM	3.07 mL	15.33 mL	30.66 mL
5 mM	0.61 mL	3.07 mL	6.13 mL

*The above data is based on the productmolecular weight 326.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.