AZD-9291 (Osimertinib)

Catalog No. A13681

AZD-9291 (Osimertinib)是第三代EGFR抑制剂，在临床前研究中显示出希望，并为已对现有EGFR抑制剂产生耐药性的晚期肺癌患者提供了希望。

Product Citations

Liu YN, .et al. Acquired resistance to EGFR tyrosine kinase inhibitors is mediated by the reactivation of STC2/JUN/AXL signaling in lung cancer, Int J Cancer, 2019, Jun 4 PMID: 31162839

Technical details

Catalog Num	A13681
M. Wt	499.61
Formula	C28H33N7O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1421373-65-0
Synonyms	AZD 9291, AZD9291
SMILES	CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC

Biological Activity

AZD-9291 (Osimertinib)是第三代EGFR抑制剂，在临床前研究中显示出希望，并为已对现有EGFR抑制剂产生耐药性的晚期肺癌患者提供了希望。

Targets

L858R/T790M EGFR (LoVo cells)	Exon 19 deletion EGFR (LoVo cells)	WT EGFR (LoVo cells)
11.44 nM	12.92 nM	493.8 nM

Solubility *

In vitro (25°C)	DMSO	Warmed: 90 mg/mL (180.14 mM)
	Water	Insoluble
	Ethanol	Warmed: 39 mg/mL (78.05 mM)
In vivo	5%DMSO+40%PEG300+5%Tween80+50%ddH2O	7.1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.02 mL	100.08 mL	200.16 mL
0.5 mM	4 mL	20.02 mL	40.03 mL
1 mM	2 mL	10.01 mL	20.02 mL
5 mM	0.4 mL	2 mL	4 mL

*The above data is based on the productmolecular weight 499.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.