AR-A 014418

Catalog No. A13728

AR-A 014418是一种选择性糖原合酶激酶3 (GSK-3) 抑制剂 (IC50 = 104 nM)。对GSK-3的特异性超过cdk2和cdk5（IC50值> 100μM）以及26种其他激酶。抑制β-淀粉样蛋白介导的海马片神经变性。

Product Citations

Chia-Hui Huang, .et al. Arsenic Trioxide-Induced p38 MAPK and Akt Mediated MCL1 Downregulation Causes Apoptosis of BCR-ABL1-positive Leukemia Cells, Toxicol Appl Pharmacol, 2020, Apr 17;397:115013 PMID: 32305283

Technical details

Catalog Num	A13728
M. Wt	308.31
Formula	C12H12N4O4S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	487021-52-3
Synonyms	AR-A014418, ARA 014418, ARA014418
SMILES	COC1=CC=C(C=C1)CNC(=O)NC2=NC=C(S2)[N+](=O)[O-]

Biological Activity

Targets

GSK-3β (Cell-free assay)	GSK-3β (Cell-free assay)
38 nM(Ki)	38 nM(Ki)

Solubility *

In vitro	DMSO	55 mg/mL (178.39 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	32.43 mL	162.17 mL	324.35 mL
0.5 mM	6.49 mL	32.43 mL	64.87 mL
1 mM	3.24 mL	16.22 mL	32.43 mL
5 mM	0.65 mL	3.24 mL	6.49 mL

*The above data is based on the productmolecular weight 308.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.