R428

Catalog No. A13741

R428是Axl激酶的选择性小分子抑制剂，在转移性乳腺癌模型中显示出阻断肿瘤扩散和延长生存期的活性。

Technical details

Catalog Num	A13741
M. Wt	506.64
Formula	C30H34N8
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1037624-75-1
Synonyms	BGB324, BGB 324, BGB-324, R-428
SMILES	C1CCN(C1)[C@H]2CCC3=C(CC2)C=C(C=C3)NC4=NN(C(=N4)N)C5=NN=C6C(=C5)CCCC7=CC=CC=C76

Biological Activity

R428是Axl激酶的选择性小分子抑制剂，在转移性乳腺癌模型中显示出阻断肿瘤扩散和延长生存期的活性。

Targets

Axl
14 nM

Solubility *

In vitro (25°C)	DMSO	Warmed: 6 mg/mL (11.84 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+corn oil	1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.74 mL	98.69 mL	197.38 mL
0.5 mM	3.95 mL	19.74 mL	39.48 mL
1 mM	1.97 mL	9.87 mL	19.74 mL
5 mM	0.39 mL	1.97 mL	3.95 mL

*The above data is based on the productmolecular weight 506.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.