MS436

Catalog No. A13749

MS436是用于BRD4溴结构域的重氮基小分子抑制剂，Ki值为30-50 nM。

Technical details

Catalog Num	A13749
M. Wt	383.42
Formula	C18H17N5O3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1395084-25-9
Synonyms	MS 436, MS-436
SMILES	CC1=C/C(=N/NC2=CC=C(C=C2)S(=O)(=O)NC3=CC=CC=N3)/C(=CC1=O)N

Biological Activity

MS436是用于BRD4溴结构域的重氮基小分子抑制剂，Ki值为30-50 nM。

Targets

BRD4 (1)	BRD4 (2)
<0.085 μM(Ki)	0.34 μM(Ki)

Solubility *

In vitro	DMSO	50 mg/mL (130.4 mM)
	Water	Insoluble
	Ethanol	Warmed: 1 mg/mL (2.6 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.08 mL	130.41 mL	260.81 mL
0.5 mM	5.22 mL	26.08 mL	52.16 mL
1 mM	2.61 mL	13.04 mL	26.08 mL
5 mM	0.52 mL	2.61 mL	5.22 mL

*The above data is based on the productmolecular weight 383.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.