Etoricoxib

Catalog No. A13770

Etoricoxib特异性结合并抑制环氧合酶2（COX-2），从而抑制花生四烯酸向前列腺素的转化。抑制COX-2可以诱导细胞凋亡并抑制肿瘤细胞的增殖和血管生成。

Technical details

Catalog Num	A13770
M. Wt	358.84
Formula	C18H15ClN2O2S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	202409-33-4
Synonyms	Arcoxia, MK-663, MK-0663
SMILES	CC1=NC=C(C=C1)C2=NC=C(C=C2C3=CC=C(C=C3)S(=O)(=O)C)Cl

Biological Activity

Etoricoxib特异性结合并抑制环氧合酶2（COX-2），从而抑制花生四烯酸向前列腺素的转化。抑制COX-2可以诱导细胞凋亡并抑制肿瘤细胞的增殖和血管生成。

Targets

COX-2

Solubility *

In vitro	DMSO	70 mg/mL (195.06 mM)
	Water	Insoluble
	Ethanol	46 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.87 mL	139.34 mL	278.68 mL
0.5 mM	5.57 mL	27.87 mL	55.74 mL
1 mM	2.79 mL	13.93 mL	27.87 mL
5 mM	0.56 mL	2.79 mL	5.57 mL

*The above data is based on the productmolecular weight 358.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.