CEP-32496

Catalog No. A13772

CEP-32496是一种口服v-raf鼠肉瘤病毒癌基因同源物B1（B-raf）丝氨酸/苏氨酸蛋白激酶抑制剂，具有潜在的抗肿瘤活性。

Technical details

Catalog Num	A13772
M. Wt	553.92
Formula	C24H23ClF3N5O5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1188910-76-0
Synonyms	CEP32496, CEP 32496, AC013773, AC 013773, AC-013773
SMILES	CC(C)(C1=CC(=NO1)NC(=O)NC2=CC(=CC=C2)OC3=NC=NC4=CC(=C(C=C43)OC)OC)C(F)(F)F

Biological Activity

CEP-32496是一种口服v-raf鼠肉瘤病毒癌基因同源物B1（B-raf）丝氨酸/苏氨酸蛋白激酶抑制剂，具有潜在的抗肿瘤活性。

Targets

Target	Value
c-Kit	Kd	2nM
LCK	Kd	2nM
PDGFRβ	Kd	2nM
RET	Kd	2nM
Abl1	Kd	3nM
VEGFR2	Kd	8nM
CSF-1R	Kd	9nM
B-Raf(V600E)	Kd	14nM
EphA2	Kd	14nM
EGFR	Kd	22nM
B-Raf	Kd	36nM
C-Raf	Kd	39nM
c-Met	Kd	513nM
JAK2	Kd	4.7μM
MEK1	Kd	7.1μM
MEK2	Kd	8.3μM
JAK1	Kd	>10μM
JAK3	Kd	>10μM
ALK	Kd	>10μM
AuroraA	Kd	>10μM
AuroraB	Kd	>10μM
ERK1	Kd	>10μM
ERK2	Kd	>10μM
IGF-1R	Kd	>10μM
INSR	Kd	>10μM
PIK3-CA	Kd	>10μM
PIK3-CB	Kd	>10μM
PLK1	Kd	>10μM

Solubility *

In vitro (25°C)	DMSO	8 mg/mL (15.46 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	15% Captisol	14 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.05 mL	90.27 mL	180.53 mL
0.5 mM	3.61 mL	18.05 mL	36.11 mL
1 mM	1.81 mL	9.03 mL	18.05 mL
5 mM	0.36 mL	1.81 mL	3.61 mL

*The above data is based on the productmolecular weight 553.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.