GO6983

Catalog No. A13790

GO6983是有效的蛋白激酶C（PKC）抑制剂。它减少了心肌缺血/再灌注损伤后多形核白细胞的粘附和浸润。

Product Citations

Kouki Kawakami, .et al. Heterotrimeric Gq proteins act as a switch for GRK5/6 selectivity underlying β-arrestin transducer bias, Nat Commun, 2022, 13: 487 PMID: 35078997

Technical details

Catalog Num	A13790
M. Wt	442.51
Formula	C26H26N4O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	133053-19-7
Synonyms	Go-6983, Go 6983
SMILES	CN(C)CCCN1C=C(C2=C1C=CC(=C2)OC)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54

Biological Activity

GO6983是有效的蛋白激酶C（PKC）抑制剂。它减少了心肌缺血/再灌注损伤后多形核白细胞的粘附和浸润。

Targets

Target	Value
PKCγ	IC50: 6nM
PKCα	IC50: 7nM
PKCβ	IC50: 7nM
PKCδ	IC50: 10nM
PKCζ	IC50: 60nM
PKCμ	IC50: 20μM

Solubility *

In vitro (25°C)	DMSO	55 mg/mL (124.29 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.6 mL	112.99 mL	225.98 mL
0.5 mM	4.52 mL	22.6 mL	45.2 mL
1 mM	2.26 mL	11.3 mL	22.6 mL
5 mM	0.45 mL	2.26 mL	4.52 mL

*The above data is based on the productmolecular weight 442.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.