Icotinib

Catalog No. A13825

Icotinib是一种有效的特异性EGFR抑制剂，IC50为5 nM，包括EGFR，EGFR（L858R），EGFR（L861Q），EGFR（T790M）和EGFR（T790M，L858R）。

Technical details

Catalog Num	A13825
M. Wt	391.42
Formula	C22H21N3O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	610798-31-7
Synonyms	BPI-2009H
SMILES	C#CC1=CC(=CC=C1)NC2=NC=NC3=CC4=C(C=C32)OCCOCCOCCO4

Biological Activity

Icotinib是一种有效的特异性EGFR抑制剂，IC50为5 nM，包括EGFR，EGFR（L858R），EGFR（L861Q），EGFR（T790M）和EGFR（T790M，L858R）。

Targets

EGFR
5 nM

Solubility *

In vitro (25°C)	DMSO	66 mg/mL (168.61 mM)
	Water	Insoluble
	Ethanol	6 mg/mL (15.33 mM)
In vivo	0.5% CMC	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.55 mL	127.74 mL	255.48 mL
0.5 mM	5.11 mL	25.55 mL	51.1 mL
1 mM	2.55 mL	12.77 mL	25.55 mL
5 mM	0.51 mL	2.55 mL	5.11 mL

*The above data is based on the productmolecular weight 391.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.