Obeticholic Acid

Catalog No. A13866

Obeticholic Acid是一种有效的选择性法呢类X受体（FXR）激动剂，EC50为99 nM。

Product Citations

Tomasz Kostrzewski, .et al. A Microphysiological System for Studying Nonalcoholic Steatohepatitis, Hepatol Commun, 2019, 13 November

Technical details

Catalog Num	A13866
M. Wt	420.63
Formula	C26H44O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	459789-99-2
Synonyms	INT-747, 6-ECDCA
SMILES	CC[C@@H]1[C@@H]2C[C@@H](CC[C@@]2([C@H]3CC[C@]4([C@H]([C@@H]3[C@@H]1O)CC[C@@H]4[C@H](C)CCC(=O)O)C)C)O

Biological Activity

Obeticholic Acid是一种有效的选择性法呢类X受体（FXR）激动剂，EC50为99 nM。

Targets

FXR
99 nM(EC50)

Solubility *

In vitro	DMSO	76 mg/mL (180.68 mM)
	Water	Insoluble
	Ethanol	Warmed: 76 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.77 mL	118.87 mL	237.74 mL
0.5 mM	4.75 mL	23.77 mL	47.55 mL
1 mM	2.38 mL	11.89 mL	23.77 mL
5 mM	0.48 mL	2.38 mL	4.75 mL

*The above data is based on the productmolecular weight 420.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.