Glasdegib (PF-04449913)

Catalog No. A13881

PF-04449913是有效且口服可生物利用的平滑化抑制剂。

Technical details

Catalog Num	A13881
M. Wt	374.18
Formula	C21H22N6O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1095173-27-5
Synonyms	PF-4449913,PF04449913
SMILES	CN1CC[C@H](C[C@@H]1C2=NC3=CC=CC=C3N2)NC(=O)NC4=CC=C(C=C4)C#N

Biological Activity

PF-04449913是有效且口服可生物利用的平滑化抑制剂。

Targets

Smoothened
5 nM

Solubility *

In vitro	DMSO	46 mg/mL (122.85 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.73 mL	133.63 mL	267.25 mL
0.5 mM	5.35 mL	26.73 mL	53.45 mL
1 mM	2.67 mL	13.36 mL	26.73 mL
5 mM	0.53 mL	2.67 mL	5.35 mL

*The above data is based on the productmolecular weight 374.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.