GS-9973 (Entospletinib)

Catalog No. A13884

GS-9973 (Entospletinib)是一种口服酪氨酸激酶（Syk）抑制剂，具有潜在的抗肿瘤活性。

Technical details

Catalog Num	A13884
M. Wt	411.46
Formula	C23H21N7O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1229208-44-9
Synonyms	GS9973, GS 9973, Entospletinib
SMILES	C1COCCN1C2=CC=C(C=C2)NC3=NC(=CN4C3=NC=C4)C5=CC6=C(C=C5)C=NN6

Biological Activity

GS-9973 (Entospletinib)是一种口服酪氨酸激酶（Syk）抑制剂，具有潜在的抗肿瘤活性。

Targets

Syk (Cell-free assay)
7.7 nM

Solubility *

In vitro (25°C)	DMSO	Warmed: 26 mg/mL (63.18 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+30% PEG 300+5% Tween 80+ddH2O	2.3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.3 mL	121.52 mL	243.04 mL
0.5 mM	4.86 mL	24.3 mL	48.61 mL
1 mM	2.43 mL	12.15 mL	24.3 mL
5 mM	0.49 mL	2.43 mL	4.86 mL

*The above data is based on the productmolecular weight 411.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.