Apabetalone (RVX-208)

Catalog No. A13956

RVX-208是一种有效的BET溴结构域抑制剂，对BD2的IC50为0.510 uM，是BD1选择性的170倍。

Technical details

Catalog Num	A13956
M. Wt	370.4
Formula	C20H22N2O5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1044870-39-4
Synonyms	RVX-000222
SMILES	CC1=CC(=CC(=C1OCCO)C)C2=NC(=O)C3=C(C=C(C=C3N2)OC)OC

Biological Activity

RVX-208是一种有效的BET溴结构域抑制剂，对BD2的IC50为0.510 uM，是BD1选择性的170倍。

Targets

BD2 (Cell-free assay)
0.51 μM

Solubility *

In vitro (25°C)	DMSO	63 mg/mL (170.08 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% CMC Na (1N HCl, PH 2.5-3.0)	7 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27 mL	134.99 mL	269.98 mL
0.5 mM	5.4 mL	27 mL	54 mL
1 mM	2.7 mL	13.5 mL	27 mL
5 mM	0.54 mL	2.7 mL	5.4 mL

*The above data is based on the productmolecular weight 370.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.