Decernotinib

Catalog No. A14012

Decernotinib是Vertex开发的口服选择性Janus激酶3（JAK3）抑制剂。

Technical details

Catalog Num	A14012
M. Wt	392.38
Formula	C18H19F3N6O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	944842-54-0
Synonyms	VX-509, VX509, VX 509, VRT-831509, VRT831509, VRT 831509
SMILES	CC[C@](C)(C(=O)NCC(F)(F)F)NC1=NC(=NC=C1)C2=CNC3=C2C=CC=N3

Biological Activity

Decernotinib是Vertex开发的口服选择性Janus激酶3（JAK3）抑制剂。

Targets

JAK3	JAK1	JAK1	JAK2	TYK2
2.5 nM(Ki)	11 nM	11 nM(Ki)	13 nM(Ki)	13 nM(Ki)

Solubility *

In vitro	DMSO	70 mg/mL (178.39 mM)
	Water	Insoluble
	Ethanol	Warmed: 18 mg/mL (45.87 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.49 mL	127.43 mL	254.85 mL
0.5 mM	5.1 mL	25.49 mL	50.97 mL
1 mM	2.55 mL	12.74 mL	25.49 mL
5 mM	0.51 mL	2.55 mL	5.1 mL

*The above data is based on the productmolecular weight 392.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.