AMG-925

Catalog No. A14025

AMG-925是一种有效，选择性和生物利用性的FLT3/细胞周期蛋白依赖性激酶4（CDK4）双激酶抑制剂。

Technical details

Catalog Num	A14025
M. Wt	471.55
Formula	C26H29N7O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1401033-86-0
Synonyms	AMG925, AMG 925
SMILES	CC1CCC(CC1)N2C3=C(C=CN=C3)C4=CN=C(N=C42)NC5=NC6=C(CN(CC6)C(=O)CO)C=C5

Biological Activity

AMG-925是一种有效，选择性和生物利用性的FLT3/细胞周期蛋白依赖性激酶4（CDK4）双激酶抑制剂。

Targets

FLT3	CDK4	CDK1
1 nM	3 nM	2.22 μM

Solubility *

In vitro (25°C)	DMSO	0.01 mg/mL (0.02 mM)
	Water	<1 mg/mL
	Ethanol	Insoluble
In vivo	2% hydroxypropyl methylcellulose+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.21 mL	106.03 mL	212.07 mL
0.5 mM	4.24 mL	21.21 mL	42.41 mL
1 mM	2.12 mL	10.6 mL	21.21 mL
5 mM	0.42 mL	2.12 mL	4.24 mL

*The above data is based on the productmolecular weight 471.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.