WHI-P 154

Catalog No. A14049

WHI-P 154是一种JAK3抑制剂，IC50 = 1.8uM。WHI-P 154还在体外抑制巨噬细胞中的STAT1激活，iNOS表达和NO生成。

Technical details

Catalog Num	A14049
M. Wt	376.2
Formula	C16H14BrN3O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	211555-04-3
Synonyms	WHI-P154
SMILES	COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)O)Br)OC

Biological Activity

WHI-P 154是一种JAK3抑制剂，IC50 = 1.8uM。WHI-P 154还在体外抑制巨噬细胞中的STAT1激活，iNOS表达和NO生成。

Targets

EGFR	VEGFR	Src	JAK3
4 nM	100 nM	100 nM	1.8 μM

Solubility *

In vitro (25°C)	DMSO	74 mg/mL (196.7 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.58 mL	132.91 mL	265.82 mL
0.5 mM	5.32 mL	26.58 mL	53.16 mL
1 mM	2.66 mL	13.29 mL	26.58 mL
5 mM	0.53 mL	2.66 mL	5.32 mL

*The above data is based on the productmolecular weight 376.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.