SD-208

Catalog No. A14066

SD-208是一种有效的ATP竞争性转化生长因子-β受体1（TGF-βRI）抑制剂（IC50 = 49 nM）；与TGF-βRII和其他常见激酶相比，分别显示出> 100倍和> 17倍的选择性。

Technical details

Catalog Num	A14066
M. Wt	352.75
Formula	C17H10ClFN6
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	627536-09-8
Synonyms	SD 208, SD208
SMILES	C1=CC(=C(C=C1Cl)C2=NC3=NC=CN=C3C(=N2)NC4=CC=NC=C4)F

Biological Activity

SD-208是一种有效的ATP竞争性转化生长因子-β受体1（TGF-βRI）抑制剂（IC50 = 49 nM）；与TGF-βRII和其他常见激酶相比，分别显示出> 100倍和> 17倍的选择性。

Targets

TGF-βRI (ALK5)
48 nM

Solubility *

In vitro (25°C)	DMSO	Warmed: 8 mg/mL (22.68 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% methylcellulose	7 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.35 mL	141.74 mL	283.49 mL
0.5 mM	5.67 mL	28.35 mL	56.7 mL
1 mM	2.83 mL	14.17 mL	28.35 mL
5 mM	0.57 mL	2.83 mL	5.67 mL

*The above data is based on the productmolecular weight 352.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.