SB-742457

Catalog No. A14092

SB-742457是一种选择性的5-HT6受体拮抗剂，具有认知，记忆和增强学习的作用。

Technical details

Catalog Num	A14092
M. Wt	353.444
Formula	C19H19N3O2S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	607742-69-8
Synonyms	GSK 742457, SB742457, SB 742457, GSK742457, SB-742,457
SMILES	C1CN(CCN1)C2=CC=CC3=CC(=CN=C32)S(=O)(=O)C4=CC=CC=C4

Biological Activity

SB-742457是一种选择性的5-HT6受体拮抗剂，具有认知，记忆和增强学习的作用。

Targets

5-HT6
9.63(pKi)

Solubility *

In vitro (25°C)	DMSO	72 mg/mL (203.7 mM)
	Water	Insoluble
	Ethanol	2 mg/mL (5.65 mM)
In vivo	2% DMSO, 48% PEG300, 2% Tween 80 and 48% water	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.29 mL	141.47 mL	282.93 mL
0.5 mM	5.66 mL	28.29 mL	56.59 mL
1 mM	2.83 mL	14.15 mL	28.29 mL
5 mM	0.57 mL	2.83 mL	5.66 mL

*The above data is based on the productmolecular weight 353.444. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.