WH 4-023

Catalog No. A14117

WH-4-023是一种有效的选择性Lck/Src双重抑制剂，对Lck和Src激酶的IC50分别为2 nM/6 nM。

Technical details

Catalog Num	A14117
M. Wt	568.67
Formula	C32H36N6O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	837422-57-8
Synonyms	WH-4-023,WH4-023
SMILES	CC1=C(C(=CC=C1)C)OC(=O)N(C2=C(C=C(C=C2)OC)OC)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCN(CC5)C

Biological Activity

WH-4-023是一种有效的选择性Lck/Src双重抑制剂，对Lck和Src激酶的IC50分别为2 nM/6 nM。

Targets

Lck (Cell-free assay)	Src (Cell-free assay)
2 nM	6 nM

Solubility *

In vitro (25°C)	DMSO	Warmed: 12 mg/mL (21.1 mM)
	Water	Insoluble
	Ethanol	Warmed: 6 mg/mL (10.55 mM)
In vivo	5% DMSO+30% PEG 300+5% Tween 80+ddH2O	1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.58 mL	87.92 mL	175.85 mL
0.5 mM	3.52 mL	17.58 mL	35.17 mL
1 mM	1.76 mL	8.79 mL	17.58 mL
5 mM	0.35 mL	1.76 mL	3.52 mL

*The above data is based on the productmolecular weight 568.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.