SGI 1027

Catalog No. A14120

SGI 1027是DNMT抑制剂，对DNMT1，DNMT3A和DNMT3B的IC50分别为6、8、7.5 uM。

Technical details

Catalog Num	A14120
M. Wt	461.52
Formula	C27H23N7O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1020149-73-8
Synonyms	SGI-1027, SGI1027
SMILES	CC1=CC(=NC(=N1)N)NC2=CC=C(C=C2)NC(=O)C3=CC=C(C=C3)NC4=CC=NC5=CC=CC=C54

Biological Activity

SGI 1027是DNMT抑制剂，对DNMT1，DNMT3A和DNMT3B的IC50分别为6、8、7.5 uM。

Targets

DNMT1 (Cell-free assay)	DNMT3B (Cell-free assay)	DNMT3A (Cell-free assay)
6 μM	7.5 μM	8 μM

Solubility *

In vitro (25°C)	DMSO	85 mg/mL (184.17 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+2% Tween 80+ddH2O	1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.67 mL	108.34 mL	216.68 mL
0.5 mM	4.33 mL	21.67 mL	43.34 mL
1 mM	2.17 mL	10.83 mL	21.67 mL
5 mM	0.43 mL	2.17 mL	4.33 mL

*The above data is based on the productmolecular weight 461.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.