Piperlongumine

Catalog No. A14124

Piperlongumine，存在于胡椒科植物荜茇中的一种天然生物碱，能够增加reactive oxygen species (ROS)水平，并选择性杀死癌细胞。它还是TrxR1的直接抑制剂，对胃癌具有抑制活性；一种新型的CRM1抑制剂；在人类乳腺癌细胞中可抑制PI3K/Akt/mTOR。

Technical details

Catalog Num	A14124
M. Wt	317.3
Formula	C17H19NO5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	20069-09-4
Synonyms	Piplartine
SMILES	COC1=CC(=CC(=C1OC)OC)C=CC(=O)N2CCC=CC2=O

Biological Activity

Targets

reactive oxygen species (ROS)

Solubility *

In vitro (25°C)	DMSO	Warmed: 15 mg/mL (47.26 mM)
	Water	Insoluble
	Ethanol	Warmed: 6 mg/mL (18.9 mM)
In vivo	2% DMSO+40% PEG 300+2% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	31.52 mL	157.58 mL	315.16 mL
0.5 mM	6.3 mL	31.52 mL	63.03 mL
1 mM	3.15 mL	15.76 mL	31.52 mL
5 mM	0.63 mL	3.15 mL	6.3 mL

*The above data is based on the productmolecular weight 317.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.