GSK1324726A (I-BET726)

Catalog No. A14133

GSK1324726A (I-BET726)是一种新型、高效、选择性的BET蛋白小分子抑制剂,对BRD2(IC50 = 41 nM)、BRD3(IC50 = 31 nM)和BRD4(IC50 = 22 nM)具有高度的亲和力。
  • Zhengjun Liu, .et al. I-BET726 Suppresses Human Skin Squamous Cell Carcinoma Cell Growth in Vitro and in Vivo, Cell Death Dis, 2020, May 5;11(5):318 PMID: 32371868
Catalog Num A14133
M. Wt 434.91
Formula C25H23ClN2O3
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1300031-52-0
Synonyms I-BET726, GSK 1324726A, GSK-1324726A, I-BET 726
SMILES CC1CC(C2=C(N1C(=O)C)C=CC(=C2)C3=CC=C(C=C3)C(=O)O)NC4=CC=C(C=C4)Cl
GSK1324726A (I-BET726)是一种新型、高效、选择性的BET蛋白小分子抑制剂,对BRD2(IC50 = 41 nM)、BRD3(IC50 = 31 nM)和BRD4(IC50 = 22 nM)具有高度的亲和力。
Targets
BRD4 BRD3 BRD2
22 nM31 nM41 nM
In vitro DMSO 77 mg/mL (177.05 mM)
Water Insoluble
Ethanol 77 mg/mL (177.05 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.99 mL 114.97 mL 229.93 mL
0.5 mM 4.6 mL 22.99 mL 45.99 mL
1 mM 2.3 mL 11.5 mL 22.99 mL
5 mM 0.46 mL 2.3 mL 4.6 mL

*The above data is based on the productmolecular weight 434.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.