GSK1324726A (I-BET726)
Catalog No. A14133
GSK1324726A (I-BET726)是一种新型、高效、选择性的BET蛋白小分子抑制剂,对BRD2(IC50 = 41 nM)、BRD3(IC50 = 31 nM)和BRD4(IC50 = 22 nM)具有高度的亲和力。
- Zhengjun Liu, .et al. I-BET726 Suppresses Human Skin Squamous Cell Carcinoma Cell Growth in Vitro and in Vivo, Cell Death Dis, 2020, May 5;11(5):318 PMID: 32371868
Catalog Num | A14133 |
---|---|
M. Wt | 434.91 |
Formula | C25H23ClN2O3 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 1300031-52-0 |
Synonyms | I-BET726, GSK 1324726A, GSK-1324726A, I-BET 726 |
SMILES | CC1CC(C2=C(N1C(=O)C)C=CC(=C2)C3=CC=C(C=C3)C(=O)O)NC4=CC=C(C=C4)Cl |
GSK1324726A (I-BET726)是一种新型、高效、选择性的BET蛋白小分子抑制剂,对BRD2(IC50 = 41 nM)、BRD3(IC50 = 31 nM)和BRD4(IC50 = 22 nM)具有高度的亲和力。
Targets
BRD4 | BRD3 | BRD2 | ||
22 nM | 31 nM | 41 nM |
In vitro | DMSO | 77 mg/mL (177.05 mM) | |
Water | Insoluble | ||
Ethanol | 77 mg/mL (177.05 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 22.99 mL | 114.97 mL | 229.93 mL |
0.5 mM | 4.6 mL | 22.99 mL | 45.99 mL |
1 mM | 2.3 mL | 11.5 mL | 22.99 mL |
5 mM | 0.46 mL | 2.3 mL | 4.6 mL |
*The above data is based on the productmolecular weight 434.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.