GDC-0152

Catalog No. A14135

GDC-0152是caspases（Smac）的第二个线粒体激活物，具有潜在的抗肿瘤活性。

Technical details

Catalog Num	A14135
M. Wt	498.64
Formula	C25H34N6O3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	873652-48-3
Synonyms	GDC0152, GDC 0152
SMILES	CC(C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C(=O)NC3=C(N=NS3)C4=CC=CC=C4)NC

Biological Activity

GDC-0152是caspases（Smac）的第二个线粒体激活物，具有潜在的抗肿瘤活性。

Targets

Target	Value
MLXBIR3SG	ki: 14nM
cIAP1-BIR3	ki: 17nM
XIAP-BIR3	ki: 28nM
cIAP2-BIR3	ki: 43nM
XIAP-BIR2	ki: 112nM
cIAP2-BIR2	ki: 9.6μM
cIAP1-BIR2	ki: 14.5μM

Solubility *

In vitro (25°C)	DMSO	98 mg/mL (196.53 mM)
	Water	3 mg/mL (6.01 mM)
	Ethanol	98 mg/mL (196.53 mM)
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.05 mL	100.27 mL	200.55 mL
0.5 mM	4.01 mL	20.05 mL	40.11 mL
1 mM	2.01 mL	10.03 mL	20.05 mL
5 mM	0.4 mL	2.01 mL	4.01 mL

*The above data is based on the productmolecular weight 498.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.