GNE 9605

Catalog No. A14149

GNE-9605是一种高效且选择性强的富含亮氨酸的重复激酶2（LRRK2）抑制剂，Ki和IC50分别为2 nM和19 nM。

Technical details

Catalog Num	A14149
M. Wt	449.83
Formula	C17H20ClF4N7O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1536200-31-3
Synonyms	GNE-9605,GNE9605
SMILES	CNC1=NC(=NC=C1C(F)(F)F)NC2=C(N(N=C2)[C@H]3CCN(C[C@@H]3F)C4COC4)Cl

Biological Activity

GNE-9605是一种高效且选择性强的富含亮氨酸的重复激酶2（LRRK2）抑制剂，Ki和IC50分别为2 nM和19 nM。

Targets

LRRK2	LRRK2
2 nM(Ki)	19 nM

Solubility *

In vitro	DMSO	84 mg/mL (186.73 mM)
	Water	Insoluble
	Ethanol	Warmed: 11 mg/mL (24.45 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.23 mL	111.15 mL	222.31 mL
0.5 mM	4.45 mL	22.23 mL	44.46 mL
1 mM	2.22 mL	11.12 mL	22.23 mL
5 mM	0.44 mL	2.22 mL	4.45 mL

*The above data is based on the productmolecular weight 449.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.