THZ1
Catalog No. A14192
THZ1是一种新型的选择性强效共价CDK7抑制剂,IC50(结合亲和力)为3.2 nM。抑制Jurkat细胞的增殖,IC50为50 nM。
Catalog Num | A14192 |
---|---|
M. Wt | 566.05 |
Formula | C31H28ClN7O2 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 1604810-83-4 |
Synonyms | THZ-1,THZ 1 |
SMILES | CN(C)C/C=C/C(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)C4=CNC5=CC=CC=C54)Cl |
THZ1是一种新型的选择性强效共价CDK7抑制剂,IC50(结合亲和力)为3.2 nM。抑制Jurkat细胞的增殖,IC50为50 nM。
In vitro (25°C) | DMSO | 96 mg/mL (150.24 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 5% DMSO+45% PEG 300+ddH2O | 3 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 17.67 mL | 88.33 mL | 176.66 mL |
0.5 mM | 3.53 mL | 17.67 mL | 35.33 mL |
1 mM | 1.77 mL | 8.83 mL | 17.67 mL |
5 mM | 0.35 mL | 1.77 mL | 3.53 mL |
*The above data is based on the productmolecular weight 566.05. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.