THZ1

Catalog No. A14192

THZ1是一种新型的选择性强效共价CDK7抑制剂,IC50(结合亲和力)为3.2 nM。抑制Jurkat细胞的增殖,IC50为50 nM。
Catalog Num A14192
M. Wt 566.05
Formula C31H28ClN7O2
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1604810-83-4
Synonyms THZ-1,THZ 1
SMILES CN(C)C/C=C/C(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)C4=CNC5=CC=CC=C54)Cl
THZ1是一种新型的选择性强效共价CDK7抑制剂,IC50(结合亲和力)为3.2 nM。抑制Jurkat细胞的增殖,IC50为50 nM。
In vitro (25°C) DMSO 96 mg/mL (150.24 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5% DMSO+45% PEG 300+ddH2O 3 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.67 mL 88.33 mL 176.66 mL
0.5 mM 3.53 mL 17.67 mL 35.33 mL
1 mM 1.77 mL 8.83 mL 17.67 mL
5 mM 0.35 mL 1.77 mL 3.53 mL

*The above data is based on the productmolecular weight 566.05. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.