SB225002

Catalog No. A14209

SB225002是一种有效的选择性CXCR2拮抗剂，IC50为22 nM，可抑制白介素IL-8与CXCR2的结合，选择性是其他测试的7-TMR的150倍以上。

Technical details

Catalog Num	A14209
M. Wt	352.14
Formula	C13H10BrN3O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	182498-32-4
Synonyms	SB-225002, SB 225002
SMILES	C1=CC=C(C(=C1)NC(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])O)Br

Biological Activity

SB225002是一种有效的选择性CXCR2拮抗剂，IC50为22 nM，可抑制白介素IL-8与CXCR2的结合，选择性是其他测试的7-TMR的150倍以上。

Targets

CXCR2
22 nM

Solubility *

In vitro (25°C)	DMSO	64 mg/mL (181.74 mM)
	Water	Insoluble
	Ethanol	Warmed: 3 mg/mL (8.51 mM)
In vivo	2% DMSO+30% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.4 mL	141.99 mL	283.98 mL
0.5 mM	5.68 mL	28.4 mL	56.8 mL
1 mM	2.84 mL	14.2 mL	28.4 mL
5 mM	0.57 mL	2.84 mL	5.68 mL

*The above data is based on the productmolecular weight 352.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.