Idasanutlin (RG7388)

Catalog No. A14211

Idasanutlin (RG7388)是一种有效的选择性p53-MDM2抑制剂。

Technical details

Catalog Num	A14211
M. Wt	616.48
Formula	C31H29Cl2F2N3O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1229705-06-9
Synonyms	RG-7388
SMILES	CC(C)(C)C[C@H]1[C@]([C@H]([C@@H](N1)C(=O)NC2=C(C=C(C=C2)C(=O)O)OC)C3=C(C(=CC=C3)Cl)F)(C#N)C4=C(C=C(C=C4)Cl)F

Biological Activity

Idasanutlin (RG7388)是一种有效的选择性p53-MDM2抑制剂。

Targets

Mdm2

Solubility *

In vitro (25°C)	DMSO	88 mg/mL (142.74 mM)
	Water	Insoluble
	Ethanol	Warmed: 7 mg/mL (11.35 mM)
In vivo	5% DMSO+30% PEG 300+5% Tween 80+ddH2O	6.1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.22 mL	81.11 mL	162.21 mL
0.5 mM	3.24 mL	16.22 mL	32.44 mL
1 mM	1.62 mL	8.11 mL	16.22 mL
5 mM	0.32 mL	1.62 mL	3.24 mL

*The above data is based on the productmolecular weight 616.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.