EW-7197 (Vactosertib)

Catalog No. A14213

EW-7197是一种高效，选择性可生物利用的TGF-βI受体ALK4/ALK5抑制剂，IC50分别为13 nM和11 nM。

Product Citations

Bordignon P, .et al. Dualism of FGF and TGF-β Signaling in Heterogeneous Cancer-Associated Fibroblast Activation with ETV1 as a Critical Determinant, Cell Rep, 2019, Aug 27;28(9):2358-2372 PMID: 31461652
Morita T, .et al. Tumor Progression Is Mediated by Thymosin-β4 through a TGFβ/MRTF Signaling Axis, Mol Cancer Res, 2018, May;16(5):880-893 PMID: 29330296

Technical details

Catalog Num	A14213
M. Wt	399.42
Formula	C22H18FN7
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1352608-82-2
Synonyms	EW7197
SMILES	CC1=CC=CC(=N1)C2=C(N=C(N2)CNC3=CC=CC=C3F)C4=CN5C(=NC=N5)C=C4

Biological Activity

EW-7197是一种高效，选择性可生物利用的TGF-βI受体ALK4/ALK5抑制剂，IC50分别为13 nM和11 nM。

Targets

Target	Value
ALK5	IC50: 11nM
ALK4	IC50: 13nM
ALK1	IC50: >10μM
ALK2	IC50: >10μM
ALK3	IC50: >10μM
ALK6	IC50: >10μM

Solubility *

In vitro (25°C)	DMSO	77 mg/mL (192.77 mM)
	Water	Insoluble
	Ethanol	42 mg/mL (105.15 mM)
In vivo	1%cmc-na	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.04 mL	125.18 mL	250.36 mL
0.5 mM	5.01 mL	25.04 mL	50.07 mL
1 mM	2.5 mL	12.52 mL	25.04 mL
5 mM	0.5 mL	2.5 mL	5.01 mL

*The above data is based on the productmolecular weight 399.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.