G-749

Catalog No. A14214

G-749是一种新型有效的FLT3抑制剂，对于FLT3（WT），FLT3（D835Y）的IC50为0.4 nM，0.6 nM和1 nM。

Technical details

Catalog Num	A14214
M. Wt	521.41
Formula	C25H25BrN6O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1457983-28-6
Synonyms	G749
SMILES	CN1CCC(CC1)NC2=NC3=C(C(=O)NC=C3Br)C(=N2)NC4=CC=C(C=C4)OC5=CC=CC=C5

Biological Activity

G-749是一种新型有效的FLT3抑制剂，对于FLT3（WT），FLT3（D835Y）的IC50为0.4 nM，0.6 nM和1 nM。

Targets

Target	Value
FLT3	IC50: 0.4nM
FLT3(D835Y)	IC50: 0.6nM
Mer	IC50: 1nM
AuroraB	IC50: 6nM
RET	IC50: 9nM
VEGFR1/FLT1	IC50: 18nM
Fms	IC50: 19nM
Axl	IC50: 20nM
AuroraC	IC50: 24nM
FGFR1	IC50: 25nM
FGFR3	IC50: 30nM
VEGFR2/KDR	IC50: 39nM
c-Kit	IC50: 142nM
IGF-1R	IC50: >300nM
PDGFRα	IC50: >300nM
PDGFRβ	IC50: >300nM

Solubility *

In vitro	DMSO	Warmed: 22 mg/mL (42.19 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.18 mL	95.89 mL	191.79 mL
0.5 mM	3.84 mL	19.18 mL	38.36 mL
1 mM	1.92 mL	9.59 mL	19.18 mL
5 mM	0.38 mL	1.92 mL	3.84 mL

*The above data is based on the productmolecular weight 521.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.