URMC-099

Catalog No. A14219

URMC-099是生物利用的脑渗透混合谱系激酶（MLK）抑制剂，对于MLK1，MLK2，MLK3和DLK，IC50分别为19 nM，42 nM，14 nM和150 nM。

Product Citations

Elad Prinz, .et al. WDR62 mediates TNFα-dependent JNK activation via TRAF2-MLK3 axis, Mol Biol Cell, 2018, Oct 1; 29(20): 2470-2480 PMID: 30091641

Technical details

Catalog Num	A14219
M. Wt	421.54
Formula	C27H27N5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1229582-33-5
Synonyms	URMC 099,URMC099
SMILES	CN1CCN(CC1)CC2=CC=C(C=C2)C3=CN=C4C(=C3)C(=CN4)C5=CC6=C(C=C5)NC=C6

Biological Activity

URMC-099是生物利用的脑渗透混合谱系激酶（MLK）抑制剂，对于MLK1，MLK2，MLK3和DLK，IC50分别为19 nM，42 nM，14 nM和150 nM。

Targets

Target	Value
Abl1	IC50: 6.5nM
LRRK2	IC50: 11nM
MLK3	IC50: 14nM
MLK1	IC50: 19nM
VEGFR1/FLT1	IC50: 39nM
MLK2	IC50: 42nM
SGK	IC50: 67nM
TrkA	IC50: 85nM
AuroraA	IC50: 108nM
ROCK2	IC50: 111nM
AuroraB	IC50: 123nM
DLK	IC50: 150nM
c-Met	IC50: 177nM
IR	IC50: 200nM
SGK1	IC50: 201nM
TrkB	IC50: 217nM
AuroraC	IC50: 290nM
IGF-1R	IC50: 307nM
LCK	IC50: 333nM
MEKK2	IC50: 661nM
Syk	IC50: 731nM
ROCK1	IC50: 1030nM
CDK1	IC50: 1125nM
CDK2	IC50: 1180nM
AMPK	IC50: 1512nM
JNK1	IC50: 3280nM
Src	IC50: 4330nM
ZAP70	IC50: 5050nM
ERK2	IC50: 6290nM
GSK-3β	IC50: >10000nM
p38α	IC50: 12050nM

Solubility *

In vitro	DMSO	76 mg/mL (180.28 mM)
	Water	Insoluble
	Ethanol	5 mg/mL (11.86 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.72 mL	118.61 mL	237.23 mL
0.5 mM	4.74 mL	23.72 mL	47.45 mL
1 mM	2.37 mL	11.86 mL	23.72 mL
5 mM	0.47 mL	2.37 mL	4.74 mL

*The above data is based on the productmolecular weight 421.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.