LDC000067

Catalog No. A14273

LDC000067是一种高选择性CDK9抑制剂。

Technical details

Catalog Num	A14273
M. Wt	370.43
Formula	C18H18N4O3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1073485-20-7
Synonyms	LDC067
SMILES	COC1=CC=CC=C1C2=CC(=NC=N2)NC3=CC=CC(=C3)CS(=O)(=O)N

Biological Activity

LDC000067是一种高选择性CDK9抑制剂。

Targets

Target	Value
CDK9	IC50: 44nM
CDK2	IC50: 2.441μM
CDK1	IC50: 5.513μM
CDK4	IC50: 9.242μM
CDK6	IC50: >10μM
CDK7	IC50: >10μM

Solubility *

In vitro	DMSO	67 mg/mL (180.86 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27 mL	134.98 mL	269.96 mL
0.5 mM	5.4 mL	27 mL	53.99 mL
1 mM	2.7 mL	13.5 mL	27 mL
5 mM	0.54 mL	2.7 mL	5.4 mL

*The above data is based on the productmolecular weight 370.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.