CX-6258 HCl

Catalog No. A14275

CX-6258 HCl是一种有效的口服泛Pim激酶抑制剂，对Pim1，Pim2和Pim3的IC50为5 nM，25 nM和16 nM。

Technical details

Catalog Num	A14275
M. Wt	498.4
Formula	C26H24ClN3O3.HCl
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1353859-00-3
Synonyms	CX6258
SMILES	CN1CCCN(CC1)C(=O)C2=CC=CC(=C2)C3=CC=C(O3)/C=C/4\C5=C(C=CC(=C5)Cl)NC4=O.Cl

Biological Activity

CX-6258 HCl是一种有效的口服泛Pim激酶抑制剂，对Pim1，Pim2和Pim3的IC50为5 nM，25 nM和16 nM。

Targets

Pim1	Pim3	Pim2
5 nM	16 nM	25 nM

Solubility *

In vitro	DMSO	Warmed: 55 mg/mL (110.35 mM)
	Water	Warmed: 86 mg/mL (172.55 mM)
	Ethanol	Warmed: 1 mg/mL (2 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.06 mL	100.32 mL	200.64 mL
0.5 mM	4.01 mL	20.06 mL	40.13 mL
1 mM	2.01 mL	10.03 mL	20.06 mL
5 mM	0.4 mL	2.01 mL	4.01 mL

*The above data is based on the productmolecular weight 498.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.