SC75741

Catalog No. A14278

SC75741是有效的NF-kB抑制剂，EC50为200 nM。

Product Citations

Yajun Li, .et al. Urolithin B suppressed osteoclast activation and reduced bone loss of osteoporosis via inhibiting ERK/NF-??B pathway, Cell Prolif, 2022, Oct;55(10) PMID: 35708050
Crystal A Mendoza, .et al. The NF- κB inhibitor, SC75741, is a novel antiviral against emerging tick-borne bandaviruses, Antiviral Res, 2021, Jan;185:104993 PMID: 33296695

Technical details

Catalog Num	A14278
M. Wt	565.67
Formula	C29H23N7O2S2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	913822-46-5
Synonyms	SC 75741
SMILES	C1CN(CCC1C2=NC(=CS2)C(=O)NC3=NC4=C(N3)C=C(C=C4)C(=O)C5=CC=CC=C5)C6=NC=NC7=C6SC=C7

Biological Activity

SC75741是有效的NF-kB抑制剂，EC50为200 nM。

Targets

NF-κB
200 nM(EC50)

Solubility *

In vitro	DMSO	Warmed: 35 mg/mL (61.87 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.68 mL	88.39 mL	176.78 mL
0.5 mM	3.54 mL	17.68 mL	35.36 mL
1 mM	1.77 mL	8.84 mL	17.68 mL
5 mM	0.35 mL	1.77 mL	3.54 mL

*The above data is based on the productmolecular weight 565.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.