KN-93 Phosphate

Catalog No. A14288

KN-93 Phosphate是一种有效且特异性的Ca2+/钙调蛋白依赖性蛋白激酶II（CaMKII）抑制剂，Ki为0.37μM，对APK，PKC，MLCK或Ca2+-PDE活性无明显抑制作用。

Product Citations

Kazuki Yuasa, .et al. Targeted ablation of p38α MAPK suppresses denervation-induced muscle atrophy, Sci Rep, 2018, 8: 9037 PMID: 29899565

Technical details

Catalog Num	A14288
M. Wt	599.03
Formula	C26H29ClN2O4S. H3O4P
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1188890-41-6
Synonyms	KN93, KN 93
SMILES	[HH].CN(C/C=C/C1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC.OOP(=O)=O

Biological Activity

KN-93 Phosphate是一种有效且特异性的Ca2+/钙调蛋白依赖性蛋白激酶II（CaMKII）抑制剂，Ki为0.37μM，对APK，PKC，MLCK或Ca2+-PDE活性无明显抑制作用。

Targets

CaMKII
0.37 μM(Ki)

Solubility *

In vitro	DMSO	86 mg/mL (143.56 mM)
	Water	79 mg/mL (131.88 mM)
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.69 mL	83.47 mL	166.94 mL
0.5 mM	3.34 mL	16.69 mL	33.39 mL
1 mM	1.67 mL	8.35 mL	16.69 mL
5 mM	0.33 mL	1.67 mL	3.34 mL

*The above data is based on the productmolecular weight 599.03. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.