(S)-crizotinib

Catalog No. A14291

(S)-crizotinib是克唑替尼的（S）-对映体，是一种有效的MTH1（NUDT1）抑制剂，IC50为72 nM。

Technical details

Catalog Num	A14291
M. Wt	450.34
Formula	C21H22Cl2FN5O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1374356-45-2
Synonyms
SMILES	C[C@@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N

Biological Activity

(S)-crizotinib是克唑替尼的（S）-对映体，是一种有效的MTH1（NUDT1）抑制剂，IC50为72 nM。

Targets

MTH1 (Cell-free assay)
72 nM

Solubility *

In vitro	DMSO	Warmed: 42 mg/mL (93.26 mM)
	Water	Insoluble
	Ethanol	22 mg/mL (48.85 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.21 mL	111.03 mL	222.05 mL
0.5 mM	4.44 mL	22.21 mL	44.41 mL
1 mM	2.22 mL	11.1 mL	22.21 mL
5 mM	0.44 mL	2.22 mL	4.44 mL

*The above data is based on the productmolecular weight 450.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.