ISRIB

Catalog No. A14302

ISRIB是一种有效的选择性PERK抑制剂，IC50为5 nM。

Product Citations

Satoshi Watanabe, .et al. Resetting proteostasis with ISRIB promotes epithelial differentiation to attenuate pulmonary fibrosis, Proc Natl Acad Sci U S A, 2021, May 18;118(20) PMID: 33972447
Satoshi Watanabe, .et al. Resetting proteostasis with ISRIB prevents pulmonary fibrosis, bioRxiv, 2020, February 27

Technical details

Catalog Num	A14302
M. Wt	451.34
Formula	C22H24Cl2N2O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1597403-47-8
Synonyms
SMILES	C1CC(CCC1NC(=O)COC2=CC=C(C=C2)Cl)NC(=O)COC3=CC=C(C=C3)Cl

Biological Activity

ISRIB是一种有效的选择性PERK抑制剂，IC50为5 nM。

Targets

PERK
5 nM

Solubility *

In vitro	DMSO	4 mg/mL (8.86 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.16 mL	110.78 mL	221.56 mL
0.5 mM	4.43 mL	22.16 mL	44.31 mL
1 mM	2.22 mL	11.08 mL	22.16 mL
5 mM	0.44 mL	2.22 mL	4.43 mL

*The above data is based on the productmolecular weight 451.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.