1-Azakenpaullone

Catalog No. A14303

1-Azakenpaullone是一种有效的选择性GSK-3β抑制剂，IC50为18 nM，选择性比CDK1/cyclin B和CDK5/p25高100倍。

Technical details

Catalog Num	A14303
M. Wt	328.16
Formula	C15H10BrN3O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	676596-65-9
Synonyms
SMILES	C1C2=C(C3=C(C=CC=N3)NC1=O)NC4=C2C=C(C=C4)Br

Biological Activity

1-Azakenpaullone是一种有效的选择性GSK-3β抑制剂，IC50为18 nM，选择性比CDK1/cyclin B和CDK5/p25高100倍。

Targets

GSK-3α	GSK-3β

Solubility *

In vitro	DMSO	58 mg/mL (176.74 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	30.47 mL	152.36 mL	304.73 mL
0.5 mM	6.09 mL	30.47 mL	60.95 mL
1 mM	3.05 mL	15.24 mL	30.47 mL
5 mM	0.61 mL	3.05 mL	6.09 mL

*The above data is based on the productmolecular weight 328.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.