K02288

Catalog No. A14311

K02288是一种有效的选择性I型BMP受体抑制剂，对ALK2，ALK1和ALK6的IC50为1.1、1.8、6.4 nM。

Technical details

Catalog Num	A14311
M. Wt	352.38
Formula	C20H20N2O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1431985-92-0
Synonyms	K 02288, K-02288
SMILES	COC1=CC(=CC(=C1OC)OC)C2=C(N=CC(=C2)C3=CC(=CC=C3)O)N

Biological Activity

K02288是一种有效的选择性I型BMP受体抑制剂，对ALK2，ALK1和ALK6的IC50为1.1、1.8、6.4 nM。

Targets

Target	Value
ALK2	IC50: 1.1nM
ALK1	IC50: 1.8nM
ALK6	IC50: 6.4nM
ALK3	IC50: 34.4nM
ALK4	IC50: 302nM
ALK5	IC50: 321nM

Solubility *

In vitro	DMSO	67 mg/mL (190.13 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.38 mL	141.89 mL	283.78 mL
0.5 mM	5.68 mL	28.38 mL	56.76 mL
1 mM	2.84 mL	14.19 mL	28.38 mL
5 mM	0.57 mL	2.84 mL	5.68 mL

*The above data is based on the productmolecular weight 352.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.