WZ4003

Catalog No. A14312

WZ4003是一种高度特异性的NUAK激酶抑制剂，对于NUAK1和NUAK2的IC50为20 nM和100 nM。

Technical details

Catalog Num	A14312
M. Wt	496.99
Formula	C25H29ClN6O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1214265-58-3
Synonyms	WZ 4003, WZ-4003
SMILES	CCC(=O)NC1=CC(=CC=C1)OC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCN(CC4)C)OC

Biological Activity

WZ4003是一种高度特异性的NUAK激酶抑制剂，对于NUAK1和NUAK2的IC50为20 nM和100 nM。

Targets

NUAK1 (Cell-free assay)	NUAK2 (Cell-free assay)
20 nM	100 nM

Solubility *

In vitro	DMSO	7 mg/mL (14.08 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.12 mL	100.61 mL	201.21 mL
0.5 mM	4.02 mL	20.12 mL	40.24 mL
1 mM	2.01 mL	10.06 mL	20.12 mL
5 mM	0.4 mL	2.01 mL	4.02 mL

*The above data is based on the productmolecular weight 496.99. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.