AZ191

Catalog No. A14314

AZ191是一种有效的选择性DYRK1B抑制剂，IC50为17 nM，选择性比DYRK1A和DYRK2高5到110倍。

Technical details

Catalog Num	A14314
M. Wt	429.52
Formula	C24H27N7O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1594092-37-1
Synonyms	AZ 191, AZ-191
SMILES	CN1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=CC(=N3)C4=CN(C5=C4C=CN=C5)C)OC

Biological Activity

AZ191是一种有效的选择性DYRK1B抑制剂，IC50为17 nM，选择性比DYRK1A和DYRK2高5到110倍。

Targets

Dyrk1B (Cell-free assay)	DYRK1A (Cell-free assay)	DYRK2 (Cell-free assay)
17 nM	88 nM	1890 nM

Solubility *

In vitro	DMSO	81 mg/mL (188.58 mM)
	Water	Insoluble
	Ethanol	1 mg/mL (2.32 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.28 mL	116.41 mL	232.82 mL
0.5 mM	4.66 mL	23.28 mL	46.56 mL
1 mM	2.33 mL	11.64 mL	23.28 mL
5 mM	0.47 mL	2.33 mL	4.66 mL

*The above data is based on the productmolecular weight 429.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.