Mdivi-1

Catalog No. A14316

Mdivi-1是线粒体分裂DRP1(与动力蛋白相关的GTPase)和线粒体分裂动力蛋白I(Dnm1)的选择性细胞渗透性抑制剂,IC50为1-10 uM。
  • KOLAC UK, .et al. Chemical Inhibition of Mitochondrial Fission Improves Mitochondrial Function and Subdues Hyperglycemia Induced Stress in Placental Trophoblast Cells, Research Square, 2022, 03 Jun
Catalog Num A14316
M. Wt 353.22
Formula C15H10Cl2N2O2S
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 338967-87-6
Synonyms Mdivi 1, Mdivi1
SMILES COC1=C(C=C(C(=C1)N2C(=O)C3=CC=CC=C3NC2=S)Cl)Cl
Mdivi-1是线粒体分裂DRP1(与动力蛋白相关的GTPase)和线粒体分裂动力蛋白I(Dnm1)的选择性细胞渗透性抑制剂,IC50为1-10 uM。
Targets
Dynamin1
1 μM-10 μM
In vitro (25°C) DMSO 62 mg/mL (175.52 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5% DMSO+40% PEG 300+5% Tween 80+ddH2O 6 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.31 mL 141.55 mL 283.11 mL
0.5 mM 5.66 mL 28.31 mL 56.62 mL
1 mM 2.83 mL 14.16 mL 28.31 mL
5 mM 0.57 mL 2.83 mL 5.66 mL

*The above data is based on the productmolecular weight 353.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.