SU9516

Catalog No. A14318

SU9516是一种有效的选择性cdk2抑制剂。它抑制pRb磷酸化,导致增强的pRB/E2F复合物形成,并诱导G1和G2-M细胞周期停滞。
Catalog Num A14318
M. Wt 241.25
Formula C13H11N3O2
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 377090-84-1
Synonyms SU 9516, SU-9516
SMILES COC1=CC\2=C(C=C1)NC(=O)/C2=C\C3=CN=CN3
SU9516是一种有效的选择性cdk2抑制剂。它抑制pRb磷酸化,导致增强的pRB/E2F复合物形成,并诱导G1和G2-M细胞周期停滞。
Targets
Target Value
CDK2IC50: 22nM
CDK1IC50: 40nM
CDK4IC50: 200nM
PKCIC50: >10μM
p38IC50: >10μM
PDGFRIC50: 18μM
EGFRIC50: >100μM
In vitro DMSO 44 mg/mL (182.38 mM)
Water Insoluble
Ethanol Warmed: 11 mg/mL (45.6 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 41.45 mL 207.25 mL 414.51 mL
0.5 mM 8.29 mL 41.45 mL 82.9 mL
1 mM 4.15 mL 20.73 mL 41.45 mL
5 mM 0.83 mL 4.15 mL 8.29 mL

*The above data is based on the productmolecular weight 241.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.