PX-478 HCl

Catalog No. A14319

PX-478 HCl是HIF-1alpha抑制剂，也是具有潜在抗肿瘤活性小分子。PX-478对已建立的人类肿瘤异种移植物具有出色的活性，可提供具有HIF-1水平正相关的延长的生长延迟的肿瘤消退。PX-478是高度水溶性的分子，具有良好的i.v.，i.p.和p.o.抗肿瘤活性。

Technical details

Catalog Num	A14319
M. Wt	394.12
Formula	C13H20Cl4N2O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	685898-44-6
Synonyms	0
SMILES	C1=CC(=CC=C1C[C@@H](C(=O)O)N)[N+](CCCl)(CCCl)[O-].Cl.Cl

Biological Activity

Targets

HIF-1α

Solubility *

In vitro	DMSO	73 mg/mL (185.21 mM)
	Water	73 mg/mL (185.21 mM)
	Ethanol	73 mg/mL (185.21 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.37 mL	126.86 mL	253.73 mL
0.5 mM	5.07 mL	25.37 mL	50.75 mL
1 mM	2.54 mL	12.69 mL	25.37 mL
5 mM	0.51 mL	2.54 mL	5.07 mL

*The above data is based on the productmolecular weight 394.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.