PI-3065

Catalog No. A14338

PI-3065是p110δ激酶的小分子和选择性抑制剂，Ki值为1.5nM，IC50值为5nM。

Product Citations

Pridham KJ, .et al. PIK3CB/p110β is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844

Technical details

Catalog Num	A14338
M. Wt	506.64
Formula	C27H31FN6OS
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	955977-50-1
Synonyms	PI3065, PI 3065
SMILES	C1CC1CN2CCN(CC2)CC3=CC4=C(S3)C(=NC(=N4)C5=C(C=CC6=C5C=CN6)F)N7CCOCC7

Biological Activity

PI-3065是p110δ激酶的小分子和选择性抑制剂，Ki值为1.5nM，IC50值为5nM。

Targets

Target	Value
p110δ	IC50: 15nM
p110β	IC50: 1078nM
p110α	IC50: 2299nM
mTOR	IC50: 9082nM
DNA-PK	IC50: >10000nM
p110γ	IC50: 27542nM

Solubility *

In vitro	DMSO	Warmed: 50 mg/mL (98.68 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.74 mL	98.69 mL	197.38 mL
0.5 mM	3.95 mL	19.74 mL	39.48 mL
1 mM	1.97 mL	9.87 mL	19.74 mL
5 mM	0.39 mL	1.97 mL	3.95 mL

*The above data is based on the productmolecular weight 506.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.