Domatinostat (4SC-202)

Catalog No. A14354

4SC-202是生物利用的苯甲酰胺和人I类组蛋白脱乙酰基酶(HDACs)同工酶1、2和3的抑制剂,具有潜在的抗肿瘤活性。
Catalog Num A14354
M. Wt 447.51
Formula C23H21N5O3S
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 910462-43-0
Synonyms 0
SMILES CN1C=C(C=N1)C2=CC=C(C=C2)S(=O)(=O)N3C=CC(=C3)/C=C/C(=O)NC4=CC=CC=C4N
4SC-202是生物利用的苯甲酰胺和人I类组蛋白脱乙酰基酶(HDACs)同工酶1、2和3的抑制剂,具有潜在的抗肿瘤活性。
Targets
HDAC3 HDAC2 HDAC1
0.57 μM1.12 μM1.20 μM
In vitro (25°C) DMSO 77 mg/mL (172.06 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.35 mL 111.73 mL 223.46 mL
0.5 mM 4.47 mL 22.35 mL 44.69 mL
1 mM 2.23 mL 11.17 mL 22.35 mL
5 mM 0.45 mL 2.23 mL 4.47 mL

*The above data is based on the productmolecular weight 447.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.