LJH685

Catalog No. A14372

LJH685是一种有效，特异性和选择性的RSK抑制剂，可抑制RSK1、2和3的生化活性，IC50为4至13 nM。

Technical details

Catalog Num	A14372
M. Wt	381.42
Formula	C22H21F2N3O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1627710-50-2
Synonyms	LJH 685, LJH-685
SMILES	CN(CC1)CCN1C(C=C2)=CC=C2C3=CC=NC=C3C4=CC(F)=C(O)C(F)=C4

Biological Activity

LJH685是一种有效，特异性和选择性的RSK抑制剂，可抑制RSK1、2和3的生化活性，IC50为4至13 nM。

Targets

RSK3	RSK2	RSK1
4 nM	5 nM	6 nM

Solubility *

In vitro	DMSO	66 mg/mL (173.03 mM)
	Water	Insoluble
	Ethanol	17 mg/mL (44.57 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.22 mL	131.09 mL	262.18 mL
0.5 mM	5.24 mL	26.22 mL	52.44 mL
1 mM	2.62 mL	13.11 mL	26.22 mL
5 mM	0.52 mL	2.62 mL	5.24 mL

*The above data is based on the productmolecular weight 381.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.